Generic Clomid (Clomiphene citrate) 25/50/100mg

Application: unovulatory infertility (ovulation induction), dysfunctional uterine bleeding, amenorrhea (disgonadotrop form, secondary, post contraceptive) galaktorrhea (on the background of the pituitary tumor), polycystic ovaries (Stein syndrome - Levental), Chiari- Frommel syndrome, androgenic failure, oligospermia, for the diagnosis of pituitary gonadrop function violations.

Contraindications: hypersensitivity, severe hepatic- renal failure, uterine bleeding of unclear etiology, ovarian cyst, tumor or inadequacy of pituitary functions, pregnancy (including suspected it).

Application at pregnancy and breastfeeding: is contraindicated for pregnant.

Side effects: On the part of the nervous system and sense organs: headache, dizziness, depression, increased fatigue, anxiety, insomnia, violation of sight.
On the part of the gastrointestinal: nausea, vomiting.
On the part of the digestive system: an increase in cystic ovaries, dysmenorrhea, violations of pregnancy.
Others: blood flows, the increase in body weight, lower abdominal pain in the chest, testicles (men), hyperthermia, reversible loss of hair, skin allergic reactions.

Interaction: Compatible with releasing hormone drugs.

Overdosage: Symptoms: nausea, vomiting, sight disturbances, stomach ache.
Treatment: symptomatic therapy.

Dosing and dose: inside. To stimulate ovulation appoint 1 of 50 mg once a day before bedtime, starting with 5 - the first day of the menstrual cycle within 5 days (in the absence of the cycle - at any time) if there is no effect (ovulation does not occur within 30 days), increasing the dose to 100 mg / day or a course lengthened to 10 days. Heading dose should not exceed 750 mg. The offensive ovulation determined by the presence of two-phase basal temperature, the average cyclical raise LG products, increased levels of serum progesterone during the middle phase of probable or luteinization in women with menstrual hemorrhage amenorrhea. If ovulation occurred, but no pregnancy occurred, the course should be repeated. If held after ovulation no menstrual bleeding, should take into account a possible pregnancy. Men appoint 50 mg 1-2 times a day for 3-4 months (requires systematic monitoring spermatogramma).

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At youthful age one of the most frequent reasons of the reference of the girls to the gynecologist is dysmenorrhea. Among pathogenetic mechanisms of development of this disease the hypothesis about the low maintenance of progesterone in a lutein phase of menstrual cycle lays. Premenstrual change of a parity of sexual steroids (oestradiolum and progesterone) accompanies development of such processes, as change of rate of oxidation of free fat acids; intensifying of emission of oxytocinum, vasopressin, bradikinin, relaxin and biogenic amines in myometriums; activation of synthesis of cyclooxygenase and prostaglandinsynthetase. All above-stated processes potentiate formation and emission of prostaglandinums. Hyperprostaglandinemia causes hypoxia and myometrium ischemia that conducts to spastic reductions of an uterus, causing an anoxic pain. At group of girls with dysmenorrhea, at the low maintenance of progesterone in the second phase of a menstrual cycle, the new preparation from a number progestagens – “Duphaston” was applied. It is a derivative of natural progesterone, therefore is deprived from the by-effects inherent to other synthetic progestinums.

Application of the preparation was carried out on one of three schemes of appointment:
From 16th till 25th day of a cycle (in a dose of 10 mg/day)
From 20th till 25th day of a cycle (in a dose of 20 mg/day)
From 5th till 25th day of a cycle (in a dose of 20 mg/day)

The choice of the scheme of therapy with Duphaston has been caused by expression of deficiency of progesterone, intensity and firmness of a painful syndrome. As a result of application of a preparation, reliable cupping of a painful syndrome, termination of complaints of patients on discharges from sexual ways in a late lutein phase of menstrual cycle, overall health improvement that has allowed to avoid application of analgetics has been noticed. On the background of reception of a preparation the girls did not note an increase of mass of body, depression of libido, occurrence of acne, hirsutism. Undoubtedly, that at treatment of dysmenorrhea at girls with progesterone insufficiency it is necessary to prefer Duphaston as a preparation, which does not block ovulation and doesn’t influence the condition of a system of hemostasis.

Duphaston is rather effectively applied at endogenous shortage of progesterone in an organism, expressed by sterility at lutein failures, a premenstrual syndrome, a dysmenorrhea, an irregular menses, dysfunctional vulval and uterine bleedings, at a threat of premature abortion.

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The medical product Raloxifene (sold under name Evista), usually prescribed for preventive maintenance of a bony rarefication at women in the period after a menopause, can also lower the risk of disease by a cancer of a mammary gland at them almost on 70 % according to preliminary results presented at the annual assembly of the American Society of Clinical Oncology (ASCO).

Our bones of which a very few people thought before, now become the central problem on which the preservation of health depends. It is explained by the fact that more and more Americans live till 70, 80 and 90 years. For this reason the condition of bones at each second woman and each eighth man essentially worsens, and their durability becomes insufficient for maintenance of active independent life in the old age, a life which is not accompanied by crises and cracks, leading to physical inability.

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The two low dosed forms of the preparation Premarin (containing 0,3 or 0,45 mg of conjugate estrogens) produced by the company “Wayet” intended for replacement hormonal therapy, are approved by Food and Drug Administration (FDA) for preventive maintenance of a postmenopausal bony rarefication.

For today Premarin is accessible in various dozes for treatment of such symptoms of a postmenopausal period, as inflows, dryness, itch and burning in a vagina. Approval of the new forms of release of a preparation is based on the data of a prospective clinical trial, the results of which testify that in these dozes the preparation is as much so effective, as in the standard (0,625 mg), for preventive maintenance of a bony rarefication at women in the postmenopausal period.

Premarin is a preparation of estrogen. It contains a mix of horse estrogens of a natural origin (conjugate estrogens), which are similar to endogenous estrogen. The preparation facilitates and stops displays of a climacteric syndrome: vasomotor frustration, emotional (irritability, alarm) and urogenital symptoms (atrophic vaginitis and atrophic urethritis) associated with them.
It prevents the development of a postmenopausal bony rarefication, suppressing resorption of bones, having an effect, antagonistic to the effect of a parathyroid hormone, but does not stimulate formation of a bone fabric.

Premarin is intended for treatment of the conditions arising at women during the period of menopause and postmenopause (vasomotor frustration (rushes of blood, night hyperhidrosis, infringements of sllep, irritability, alarm); atrophic vaginitis, trophic urethritis; a postmenopausal bony rarefication; cardiovascular diseases; hypogonadism at women; primary dysfunction of ovaries.

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The irritatable intestines syndrome - frustration in the basis of which lay the infringements of sensitivity and impellent activity of intestines, is accompanied by pain in the stomach, lock or diarrhea. Prevalence of disease in the majority of the countries of the world makes 15 - 20 %, and 2/3 of the patients do not address to doctors. The peak of the disease is in the young able-bodied age - 30 - 40 years, at women the disease develops three times more often, than at men. Thus the gastroenteric path is excessively sensitive to many stimuli.

In most cases patients with a syndrome of the irritable intestine are practically healthy. The doctor at survey, as a rule, does not reveal any changes.

Zelnorm – a preparation used for short-term treatment of a syndrome of the irritated intestines at women if a leading symptom is the contamination. The syndrome of irritable intestines is an infringement of normal work of a large intestine. The symptoms may become pains in the stomach, infringements of a stool, spasms, meteorism, diarrhea. The reason of the disease is not known.
Zelnorm improves a motility of intestines, reduces a pain and discomfort in the field of the stomach, eliminates meteorism and contamination.

Indications to application
The treatment of the diseases and the sensations of discomfort in a stomach, swellings of the stomach and infringements in the work of the digestive path at patients with a syndrome of irritated intestines, which basic symptoms are the pain/discomfort and contaminations.

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Xeloda is a preparation, approved for application in more than 90 countries of the world, including the EU countries, the USA, Japan, Australia and Canada. The preparation has proved as effective, rather safe, simple and convenient medical product for application. For today Xeloda is used for treatment more than 1 million oncological patients.

In 2001 the company “Roche” has received the sanction to use Xeloda as monotherapy of the first line at treatment of patients with a metastatic colorectal cancer (a colorectal cancer with metastasises in other parts of a body) in many countries, including the EU countries and the USA. In March, 2005 the European commission, and in June of the same year and the FDA of the USA has approved Xeloda as means of adjuvant (after surgical treatment) therapies of a cancer of the large intestine.

The sanction to application of Xeloda in a combination with Taxoter (docetaxel) for treatment of women with locally spread and metastatic cancer of a mammary gland, at an inefficiency of the chemotherapy including an anthracyclinic preparation, is received.

The monotherapy with Xeloda is shown also for treatment of patients with locally spread and a metastatic cancer of a mammary gland, resistant to treatment by such chemopreparations, as taxans and antracyclines, and also for those patients to whom treatment by antracyclines is not prescribed.

Xeloda is already approved for application as the first line therapy of a cancer of a stomach in South Korea, the preparation has got the approval of the European committee of the Control over the medical products, used at the people, and now “Roche” expects for approval of indications for application of the given preparation in other countries of the world.
The first and the unique peroral tumour-activated cytostatic for effective treatment of a colorectal cancer and a cancer of the mammary gland, allowing to follow a full policy of chemotherapy in the home or outpatient conditions.

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Parlodel is a stimulator of dopamine receptors. Inhibitor of secretions of prolactin.

Indications
Infringements of a menstrual cycle, female barreness.
Parlodel-dependent diseases and the conditions which are accompanied or not accompanied by hyperparlodelemia:
– amenorrhea (accompanied and not accompanied by galactorrhea), oligomenorrhea;
– insufficiency of a lutein phase;
– hyperprolactinemic infringements caused by medical products (for example, some psychotropic or antihypertensive preparations).
Parlodel-dependent female barreness:
– a syndrome of polycystic ovaries;
– anovulatory cycles (in addition to antiestrogen, for example clomiphene).
A premenstrual syndrome:
– morbidity of mammary glands, the hypostases connected with a phase of the cycle, meteorism, infringements of mood.
Hyperprolactinemia at men:
– parlodel-dependent hypogonadism (oligospermia, loss of libido, impotency).
Prolactinomas:
– Conservative treatment of parlodel-secreting micro and macroadenoma of a hypophysis;
– Preoperative preparation for reduction of volume of a tumor and simplification of its removal;
– Postoperative treatment if the level of prolactin remains raised.
Acromegaly:
– As additional means in a complex with radiotherapy and operative treatment or, in special cases, as alternative to surgical or radiotherapy.
Suppression of a lactation:
– Prevention or the termination of a postnatal lactation under medical indications;
– Prevention of a lactation after abortion;
– Postnatal hardening of mammary glands;
– Beginning of puerperal mastitis.
Good-quality diseases of mammary glands:
– mastalgia (in the isolated kind, or in a combination with a premenstrual syndrome or good-quality central or cystic changes);
– Good-quality central and-or cystic changes, especially fibrocystic mastopathy.
Parkinson’s disease:
– All stages of an idiopathic Parkinson’s disease and postencephalitic parkinsonism either in the form of monotherapy, or in a combination with others antiparkinson means.

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When the growth of a tumoral fabric depends on the presence of estrogen, elimination of the stimulating influences mediated by them is the precondition for suppression of growth of a tumour. At women in postmenopause estrogen is formed mainly at participation of enzyme of aromatase, which transforms the androgens synthesized in adrenal glands (first of all, antrostenedione and testosterone) into estron and estradiol. Therefore it is possible to reach suppression of biosynthesis of estrogen in peripheral fabrics and in a tumoral fabric by means of specific inhibition of enzyme of aromatase.

Femara is appointed as a first line preparation of the therapy of the widespread forms of a cancer of a mammary gland at women in postmenopause.
The preparation is used for treatment of the widespread forms of a cancer of a mammary gland at women in postmenopause (natural or artificially caused), who have received the previous therapy by antiestrogen.

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Danazol is a preparation, which suppresses production of gonadotropins (luteinizing hormones and follicle-stimulating hormones) of hypophysomas, therefore there is a braking ovulation and an atrophy of an endometrium. With the purpose of emergency contraception it is recommended to accept Danazol twice in a doze of 600 mg with an interval in 12 h during 72 h after a not protected coitus. It is considered, that there are not much by-effects at the application of Danazol with the purpose of emergency contraception. Moreover Danazol may be applied by the patients with contra-indications to application of estrogen-hestagenic preparations. However, there is no a big number of messages about the application of this method available in the literature.

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Indications.
The bleedings or risk of bleedings on a background of strengthening of fibrinolysis (malignant new growths of pancreas and prostate glands, operations on organs of a thorax, postnatal bleedings, manual removal of afterbirth, leucosis, diseases of the liver, previous therapy by streptokinase - cases of generalized fibrinolysis; uterus, nasal, gastroenteric bleedings, heamturia, bleedings after prostatectomy, conization of cervix in occasion of carcinoma, extraction of a tooth at patients with hemorrhagic diathesis – cases of local fibrinolysis). Hereditary angioedema, allergic diseases (eczema, allergic dermatitis, nettle-rash, a medicinal and toxic rash), inflammatory diseases (tonsillitis, pharyngitis, laryngitis, stomatitis, aphthae of the mucous membrane of an oral cavity).

Collateral action.
A rash, a skin itch and other displays of the raised sensitivity a preparation, decrease in appetite, a nausea, a diarrhea, a heartburn, drowsiness, infringement of color sight.

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Indications to application of :
Arimidex is shown for treatment of the widespread cancer of a mammary gland at women in postmenopause, which have a progressing disease on a background of therapy by Tamoxifen or another antiestrogen. At patients with negative result of the test for receptors of estrogen the efficiency of a preparation has not been shown, except for those cases when there was a previous positive clinical answer on Tamoxifen.

The cancer of a mammary gland still takes one of the first places in a number of oncological diseases of women. Despite of tremendous successes of modern oncology, the median of survival rate of the people sick from the widespread cancer of a mammary gland remains constant during many years, and the 5-years survival rate makes only 15 %. The vital issue in the last years is also the quality of life of the patients. Therefore hormonotherapy takes the important place and it is still actual, and with the advent of new preparations its borders are considerably widening.

The growth of many forms of cancer of a mammary gland depends on a level of estrogen, therefore decrease in a level of estrogen can lead to the stop or delay of development of a tumour. At women in a postmenopause period estradiol is formed basically due to transformation of androstenedione in estrone by means of enzyme of aromatase. Arimidex is strong highly selective inhibitor of aromatase.

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Provera — derivative of progesterone, rendering a progestine action and not possessing androgenic and estrogen activity. In corresponding dozes the preparation oppresses secretion of gonadotropic hormones (especially luteinizing) and prevents ovulation. Provera ( Medroxyprogesterone ) also breaks the secretory changes of endometrium and raises viscosity of slime of cervix of the uterus. It increases the quantity of intermediate cells in an index of maturing of vaginal epithelium.

Moreover, the preparation reduces the expressiveness of vasomotor semiology at women in menopause.

Indications

• Dysfunctional (anovulatory) uterus bleedings;
• Endometriosis;
• Correction of by-effects from endometrium at therapy by estrogen in menopause;
• Differential diagnostics of primary and secondary amenorrhea.

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Gestanin - Allyloestrenol 5/25mg

Gestanin is a gestagenic preparation, which stimulates the secretory phase in myometrium, creates conditions for development of fertilized ovum. It has a tocolytic effect; reduces sensitivity of myometrium to oxytocine. It stimulates the development of acinus of mammary glands, secretory activity of trophoblasts, development of aldosterone by adrenal glands. It raises deducing of metabolites of placentary steroids and secretion of endrogenic gestagen, increases stocks of fat and recycling of glucose, promotes accumulation of glycogen by a liver, normalizes the functioning of a placenta.

The preparation has an expressed progestative effect (similar to the effect of gestagens - hormones of a yellow body of ovary) and plays a hormone-replacing role at pregnancy. Gestagens are the female sexual hormones developed by a yellow body of ovary and by cortex of adrenal glands, cause changes in endometrium (an internal layer of a uterus), preparing it to implantation (introduction) of impregnated ovum, provide normal course of pregnancy, reduce contractility of an uterus, especially pregnant, stimulate development of milk-forming departments of mammary glands. The preparation improves secretory activity of trophoblasts (an external layer of cells at a embryo) and reduces development of oxytocinase, increases the discharge of metabolites (products of exchange) of placentary steroids, that normalizes functioning of a placenta, and also stimulates secretion of endrogenic progesterone (formation in an organism of a hormone of a yellow body of ovary), promoting preservation of pregnancy.

Indications to application
Habitual and menacing abortion, threat of premature birth.

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